USS Twiggs (DD-591)
| Navy | US Navy |
| Type | Destroyer |
| Class | Fletcher |
| Pennant | DD 591 |
| Built by | Charleston Navy Yard (Charleston, South Carolina, U.S.A.) |
| Laid down | 20 Jan 1943 |
| Launched | 7 Apr 1943 |
| Commissioned | 4 Nov 1943 |
| Lost | 16 Jun 1945 |
| Loss position | 26.08N, 127.35E off the southern end of Okinawa |
| History | |
| Sunk by Japanese aircraft in position 26º08'N, 127º35'E, 125 of her crew were lost with the ship. |